Two patients, father and son, presented since childhood with slowly progressive weakness, pain, or liability to pressure
palsies. Finding were similar in father and son, but pronounced in the former. Both had pes cavus deformity. The father had
enlarged, firm peripheral nerves. Muscle strength was reduced to 4/5, being worse distally. Deep tendon reflexes were absent.
Plantar responses were flexor. All sensory modalities were impaired. In addition, multiple living male and female relatives
from four generations were affected. Myelin protein zero (MPZ) sequencing revealed a codon 96 mutation that substituted a
positively charged lysine for a negatively charged glutamate in the extracellular region.
SYMPTOMS
progressive numbness, muscle weakness and lost of function.
Reduced muscle strength.
High foot arches.
Decrease ability to run.
Currled toes.
frequent tripping and falling.
Treatment Options
Treatment options are tough because this diease is very painfull and their is no real cure. Prescription medication
is used to take away pain. People with this diease go threw Physical Threapy, Occupatinal Therapy and use orthapedic devices
(splints,Braces) to help their muscles.
Peroneal Muscular atrophy gets worse over time if not taken care of. people with this disease should exercise
regularly and do streching exercises. Wear shoes with ankle sapport t protect your feet.
